Clinical study on Huaiqihuang Granules combined with eltrombopag olamine in treatment of refractory immune thrombocytopenia in children
Objective To explore clinical effect of Huaiqihuang Granules combined with Eltrombopag Olamine Tablets in treatment of refractory immune thrombocytopenia in children.Methods Children(60 cases)with refractory immune thrombocytopenia in Hebei Children's Hospital from January 2020 to July 2022 were divided into control and treatment groups according to random number tablet method,and each group had 30 cases.Children in the control group were po administered with Eltrombopag Olamine Tablets,the initial dose was 25 mg/d,and then the dose was adjusted based on PLT count.Children in the treatment group were po administered with Huaiqihuang Granules on the basis of the control group,1 bag/time,twice daily.Patients in two groups were treated for 6 months.The clinical efficacies,PLT,and immune function in two groups were compared.Results After treatment,the total effective rate of the treatment group was significantly higher than that in the control group,with a statistically significant difference(P<0.05).After treatment,PLT in two groups was significantly higher than that before treatment(P<0.05),and PLT in treatment group was higher than that in control group(P<0.05).After treatment,the levels of CD3+,CD4+,and CD4+/CD8+ in two groups were increased,but the levels of CD8+ were decreased(P<0.05).After treatment,the levels of CD3+,CD4+,and CD4+/CD8+ in the treatment group were higher than those in the control group,and the levels of CD8+ were lower than those in the control group(P<0.05).Conclusion Huaiqihuang Granules combined with Eltrombopag Olamine Tablets has clinical effect in treatment of refractory immune thrombocytopenia in children,can rapidly increase the PLT level of children and enhance immune function.
Huaiqi Huang GranulesEltrombopag Olamine Tabletsrefractory immune thrombocytopenia in childrenPLTCD3+
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