Clinical study of Feilike Mixture combined with recombinant human interferon α1b in treatment of acute bronchiolitis in children
Objective To investigate the therapeutic effect of Feilike Mixture combined with recombinant human interferon α1b in treatment of acute bronchiolitis in children.Methods A total of 96 children with acute bronchiolitis admitted to North China Medical Health Group Fengfeng General Hospital and Dongying District People's Hospital of Dongying City from March 2020 to February 2023 were selected and divided into control group and treatment group according to random number table method,with 48 cases in each group.Patients in the control group were atomized inhaled Recombinant Human Interferon α1b for injection,2 μg/kg,twice daily.Patients in the treatment group were po administered with Feilike Mixture on the basis of the control group,10 mL/time,3 times daily.The treatment course of both groups was 7 d.The clinical efficacy and disappearance time of main symptoms and signs of the two groups were observed.The pulmonary function indexes,blood oxygen saturation(SpO2),exhaled nitric oxide(FeNO),serum intercellular adhesion molecule-1(ICAM-1),interleukin-17(IL-17),interferon gamma(INF-γ),and serum amyloid A(SAA)levels of the two groups were compared before and after treatment.Results After treatment,the total effective rate of the treatment group was 95.83% ,which was significantly higher than that of the control group(83.33% )(P<0.05).After treatment,the disappearance time of fever,cough,phlegm,shortness of breath,and lung moist rales in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,respiratory rate(RR)and breathing-to-breath ratio(Ti/Te)were significantly decreased,while tidal volume(VT)was significantly increased in both groups(P<0.05).After treatment,RR and Ti/Te in treatment group were lower than those in the control group,and VT was higher than those in the control group(P<0.05).After treatment,SpO2 was significantly increased,while FeNO level was significantly decreased in both groups(P<0.05).After treatment,SpO2 in the treatment group was higher than that in the control group,and FeNO level was lower than that in the control group(P<0.05).After treatment,serum ICAM-1,IL-17 and SAA levels were significantly decreased,while serum IFN-γ levels were significantly increased in both groups(P<0.05).After treatment,the serum ICAM-1,IL-17 and SAA levels in treatment group were significantly lower than those in control group,and the serum IFN-γ levels were significantly higher than those in control group(P<0.05).Conclusion Feilike Mixture combined with recombinant human interferon α1b has good clinical efficacy in treatment of acute bronchiolitis in children,can effectively promote the reduction of the main symptoms and signs and the improvement of lung ventilation function,and effectively control the inflammatory response of the body with good tolerance,which is worthy of clinical promotion and application.
Feilike MixtureRecombinant Human Interferon α1b for injectionacute bronchiolitisSpO2FeNOICAM-1IL-17INF-γ
NETL
NSTL
万方数据
维普
