Clinical study of Tongxuan Lifei Granules combined with cefprozil in treatment of children with acute upper respiratory tract infection
Objective To explore the clinical efficacy of Tongxuan Lifei Granules combined with cefprozil in treatment of children with acute upper respiratory tract infection.Methods A total of 226 children with acute upper respiratory tract infection admitted to the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from January 2021 to October 2022 were selected and divided into control group and treatment group according to random number table method,with 113 cases in each group.Patients in control group were po administered with Cefprozil Granules,7.5 mg/kg each time,twice daily.Patients in the treatment group were po administered with Tongxuan Lifei Granules on the basis of the control group,1—3 years old 1/3 bag/time;4—6 years old 1/2 bag/time;over 7 years old 1 bag/time;twice daily.The treatment course of both groups was 5 d.The clinical efficacy and disappearance time of main manifestations were observed in the two groups.The Sleep Habits Questionnaire(CSHQ)scores,Children's Mental Health Scale(MHS-CA)scores,and Children's Quality of Life Scale 4.0(Peds QLTM4.0)scores,whole blood white blood cell count(WBC),neutrophil ratio(NEUT% ),C-reactive protein(CRP),and procalcitonin(PCT)were compared between two groups before and after treatment.Results After treatment,the total effective rate of treatment group was 96.46% ,which was significantly higher than that of control group(88.50% ,P<0.05).The disappearance time offever,cough,sore throat,stuffy nose,and runny nose in treatment group was significantly shorter than that in control group(P<0.05).After treatment,CSHQ scores were significantly decreased in both groups,but MHS-CA and Peds QLTM4.0 scores were significantly increased(P<0.05).After treatment,CSHQ,MHS-CA and Peds QLTM4.0 scores were significantly improved in treatment group(P<0.05).After treatment,whole blood WBC,NEUT% ,CRP,and PCT levels were significantly decreased in both groups(P<0.05).After treatment,the levels of WBC,NEUT% ,CRP,and PCT in treatment group were lower than those in control group(P<0.05).Conclusion Tongxuan Lifei Granules combined with cefprozil has good clinical efficacy in treatment of children with acute upper respiratory tract infection,and can effectively accelerate the disappearance of the main clinical manifestations of children,inhibit the infection and inflammation of the body,and effectively improve the sleep,psychology and quality of life,which is worthy of clinical promotion and application.
NETL
NSTL
万方数据
维普
