Clinical study of Xiao'er Resuqing Granules combined with oseltamivir in treatment of influenza in children
Objective To explore the clinical efficacy of Xiao'er Resuqing Granules combined with oseltamivir in treatment of influenza in children.Methods A total of 98 children with influenza treated in Beijing Tongzhou District maternal and Child Health Hospital from January to May 2023 were selected and divided into control group and treatment group according to random number table method,with 49 cases in each group.Children in control group were po administered with Oseltamivir Phosphate Granules,body weight≤15 kg 30 mg/time,15—23 kg 45 mg/time,23—40 kg 60 mg/time,and>40 kg 75 mg/time,twice daily,Oseltamivir Phosphate Granules were dissolved in warm water and taken orally.Children in treatment group were po administered with Xiao'er Resuqing Granules on the basis of control group,1 bag/time for 1 to 3 years old,1.5 bags/time for 3 to 7 years old,2 bags/time for 7 to 12 years old,3 times daily.The treatment course of both groups was 5 d.The clinical effect,the time of complete fever remission and the time of disappearance of flu-like symptoms were observed in two groups.Quality of Life Scale 4.0(Peds QLTM4.0),90-item Symptom Checklist 90(SCL-90)scores,blood routine indexes and C-reactive protein(CRP)levels were compared between two groups before and after treatment.Results After treatment,the total effective rate of the treatment group was 95.92% ,which was significantly higher than that of the control group(83.67% ,P<0.05).The complete remission time of fever and the disappearance time of myalgia,headache,general discomfort,cough and sore throat in treatment group were significantly shorter than those in control group(P<0.05).After treatment,Peds QLTM4.0 was significantly increased in both groups,but SCL-90 score was significantly decreased in both groups(P<0.05).After treatment,Peds QLTM4.0 and SCL-90 scores in treatment group were better than those in control group(P<0.05).After treatment,the lymphocyte count(LYMP#)was significantly increased,but the neutrophil count(NEUT#),monocyte count(MONO#)and CRP levels were significantly decreased in both groups(P<0.05).After treatment,blood routine indexes and CRP levels were significantly improved in treatment group(P<0.05).Conclusion Xiao'er Resuqing Granules combined with oseltamivir has a definite effect in treatment of influenza in children,can rapidly reduce symptoms,help control inflammation,enhance immunity and improve the life quality and psychological state of children,which is worthy of clinical promotion and application.
Xiao'er Resuqing GranulesOseltamivir Phosphate Granulesinfluenzatime for complete regression of fevertime of disappearance of flu-like symptomPeds QLTM4.0 scoresSCL-90 scoresCRP
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万方数据
维普
