Clinical observation of Jiawei Zuojin Pills combined with rabeprazole in treatment of gastroesophageal reflux disease
Objective To explore the curative effect of Jiawei Zuojin Pills combined with rabeprazole in treatment of gastroesophageal reflux disease.Methods Patients(100 cases)with gastroesophageal reflux disease in the People's Hospital of SND from January 2021 to March 2023 were randomly divided into control(50 cases)and treatment(50 cases)group.Patients in the control group were po administered with Rabeprazole Sodium Enteric Capsules,20 mg/time,once daily.Patients in the treatment group were po administered with Jiawei Zuojin Pills on the basis of the control group,6 g/time,twice daily.Patients in two groups were treated for 8 weeks.After treatment,the clinical evaluation was evaluated,the scores of clinical symptom and SF-36 scale,resting pressure of esophageal sphincter in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 90.00% ,which was significantly higher than that of the control group(74.00% ,P<0.05).After treatment,the total score of RDQ,the scores of heartburn,regurgitation,acid reflux and chest discomfort in two groups were significantly decreased,while the scores of overall health,physiological function,physiological function,social function,emotional function,physical pain,vitality and mental health were significantly increased(P<0.05),and the clinical symptoms and the score of SF-36 scale in the treatment group were significantly better than those in the control group(P<0.05).After treatment,the resting pressure of LES and UES in two groups were significantly increased(P<0.05),and which in the treatment group were significantly higher than those in the control group(P<0.05).Conclusion Jiawei Zuojin Pills combined with rabeprazole has good effect in the treatment of gastroesophageal reflux disease,which can improve the clinical symptoms and quality of life of patients,increase the resting pressure of esophageal sphincter.
NETL
NSTL
万方数据
维普
