Clinical study of Kangfuxin Solution combined with somatostatin in treatment of acute duodenal ulcer bleeding
Objective To explore the clinical effect of Kangfuxin Solution combined with Somatostatin for injection in treatment of acute duodenal ulcer bleeding.Methods Patients(106 cases)with acute duodenal ulcer bleeding in the General Hospital of the Southern Theater Command of the Chinese People's Liberation Army from January 2020 to January 2022 were divided into control and treatment groups according to the random number table,and each group had 53 cases.Patients in the control group were first slowly injected with 0.25 mg Somatostatin for injection as loading dose,and then immediately intravenous dripped 0.25 mg/h.If the interval between infusion and infusion was greater than 3 to 5 minutes,0.25 mg Somatostatin for injection was re-administered intravenously to ensure continuity of administration.Patients in the treatment group were po administered with Kangfuxin Solution on the basis of the control group,10 mL/time,three times daily.Patients in two groups were treated for 7 d.The clinical efficacies,the changes of clinical indexes,and inflammatory factor levels in two groups were compared.Results Compared with the control group(83.02% ),total effective rate of the treatment group(98.11% )was significantly higher(P<0.05).Compared with control group,time of stool occult blood turning negative and fasting in the treatment group were shorter(P<0.05).After treatment,the serum levels of IL-6 in two groups decreased compared to before treatment(P<0.05),and those in the treatment group were lower than those in the control group(P<0.05).Conclusion Kangfuxin Solution combined with Somatostatin for injection has a more significant effect on the treatment of acute duodenal ulcer bleeding,which can effectively improve clinical symptoms and reduce the serum level of IL-6.
Kangfuxin SolutionSomatostatin for injectionacute duodenal ulcer bleedingtime of stool occult blood turning negativefasting timeIL-6
NETL
NSTL
万方数据
维普
