Clinical study on Compound Banmao Capsules combined with TAC regimen in treatment of triple negative breast cancer
Objective To investigate the efficacy of Compound Banmao Capsules combined with TAC regimen in treatment of triple negative breast cancer.Methods Patients(100 cases)with triple negative breast cancer in Dongtai Hospital of TCM from April 2020 to March 2023 were divided into control and treatment groups according to the random number table method,and each group had 50 cases.Patients in the control group was treated with TAC regimen.On the first day,patients in the control group received intravenous injection of 75 mg/m2 of Docetaxel Injection,intravenous drip of 600 mg/m2 of Cyclophosphamide for injection,and intravenous injection of 80 mg/m2 of Epirubicin Hydrochloride Injection.Patients in the treatment group were po administered with Compound Banmao Capsules on the basis of the control group,3 grains/time,twice daily.One chemotherapy cycle had 21 days,and the efficacy of the two groups was analyzed after continuous treatment for 6 cycles.The clinical efficacies,Quality of life,lymphocyte r elated indicators,tumor markers and serum indicators,and adverse reactions in two groups were compared.Results After treatment,the total effective rate of the treatment group(94.00% )was higher than that of the control group(80.00% ),and the difference between groups was significant(P<0.05).After treatment,the QLSBC score of breast cancer in two groups was lower than that before treatment(P<0.05),and the QLSBC score in the treatment group was lower than that in the control group(P<0.05).After treatment,CD8+ in the treatment group was smaller than before treatment,but LMR,CD4+,CD4+/CD8+ were larger than those before treatment(P<0.05).CD8+ in the treatment group was smaller than that in the control group,while LMR,CD4+,CD4+/CD8+ were larger than those in the control group(P<0.05).After treatment,the serum levels of CA153 and CEA in two groups were lower than those before treatment(P<0.05).The serum levels of CA153 and CEA in the treatment group were lower than those in the control group(P<0.05).After treatment,the serum levels of ADP in two groups were higher than those before treatment,but the serum levels of IL-8 were lower than before treatment(P<0.05).The serum level of ADP in the treatment group was higher than that in the control group,but the serum level of IL-8 was lower than that in the control group(P<0.05).During the treatment period,the incidence of adverse reactions in the treatment group was lower than that in the control group,and there was a significant difference between the groups(P<0.05).Conclusion Compound Banmao Capsules combined with TAC regimen is helpful to improve the efficacy of triple negative breast cancer,improve the immune function and quality of life of patients,reduce the level of tumor markers,and reduce the occurrence of adverse drug reactions.
Compound Banmao CapsulesTAC schemeDocetaxel InjectionCyclophosphamide for injectionEpirubicin Hydrochloride Injectiontriple negative breast cancerQLSBC scoreCA153CEAADPIL-8
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万方数据
维普
