Clinical study on Chuanlong Guci Tablets combined with sodium hyaluronate in treatment of knee osteoarthritis in early and middle stage
Objective To explore the clinical effect of Chuanlong Guci Tablets combine with Sodium Hyaluronate Injection in treatment of knee osteoarthritis in early and middle stage.Methods Patients(160 cases)with knee osteoarthritis in early and middle stage in Henan Provincial Chest Hospital from June 2019 to June 2021 were divided into control(80 cases)and treatment(80 cases)groups according to random number tablet method.Patients in the control group was injected with Sodium Hyaluronate Injection into the knee joint cavity,1 dose/time,once weekly.Patients in the treatment group were po administered with Chuanlong Guci Tablets on the basis of the control group,6—8/time,three times daily.Patients in two groups were treated for 5 weeks.The clinical efficacies,clinical symptoms,and serum indicators in two groups were compared.Results After treatment,the total effective rate of the treatment group(93.75% )was higher than 80.00% of the control group(P<0.05).After treatment,VAS score and WOMAC score of two groups were decreased(P<0.05),and VAS score and WOMAC score of the treatment group were lower than those of the control group(P<0.05).After treatment,the levels of ESR,CRP,β-CTX,PGE2,SP,DA,5-HT,PICP,and BGP in two groups were decreased(P<0.05),and the levels of ESR,CRP,β-CTX,PGE2,SP,DA,5-HT,PICP,and BGP in the treatment group were lower than those in the control group(P<0.05).Conclusion Chuanlong Guci Tablets combined with Sodium Hyaluronate Injection in treatment of knee osteoarthritis in early and middle stage patients can effectively improve the clinical symptoms,and regulate bone metabolism and pain mediator levels.
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万方数据
维普
