Clinical study on Xinhuang Tablets combined with ornidazole in treatment of acute pericoronitis of wisdom teeth
Objective To explore the clinical effect of Xinhuang Tablets combined with ornidazole in treatment of acute pericoronitis of wisdom teeth.Methods Patients(130 cases)with acute pericoronitis of wisdom teeth in the Branch of Tianjin Third Central Hospital from January 2019 to July 2022 were randomly divided into control(65 cases)and treatment(65 cases)group.Patients in the control group were po administered with Ornidazole Tablets,2 tablets/time,three times daily.Patients in the treatment group were po administered with Xinhuang Tablets on the basis of the control group,3 tablets/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluations was evaluated,the time of symptom relief,GI scores,serological IL-6,IL-1β,TNF-α and MMP-2 levels in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.46% ,which was significantly higher than that of the control group(84.62% ,P<0.05).After treatment,the time of symptom improvement in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the GI score in two groups was significantly lower than that before treatment(P<0.05),and which in the treatment group was significantly lower than that of the control group(P<0.05).After treatment,the levels of serum inflammatory factors IL-6,IL-1β,TNF-α and MMP-2 in two groups were significantly lower than those before treatment(P<0.05),and the factors levels in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion The synergistic treatment of Xinhuang Tablets and ornidazole is effective in improving clinical symptoms,and which can promote the weakening of gingival inflammatory response.
Xinhuang TabletsOrnidazole Tabletsacute pericoronitis of wisdom teethGIMMP-2TNF-α
NETL
NSTL
万方数据
维普
