Pharmacological effects research progress on small molecule drugs against diabetic kidney disease
Diabetes kidney disease(DKD)is a common microvascular complication of diabetes,with hidden onset.It is a progressive renal function decline disease characterized by proteinuria,and is an important risk factor leading to end-stage renal disease,cardiovascular disease,and early death.Small molecule drugs are chemically synthesized active substances with a relative molecular weight of less than 1 000,and their essence of action are the interactions between the drugs and the target proteins.Small molecule drugs can play a role in preventing and treating DKD by improving hemodynamics,anti-inflammation,anti-oxidation,anti-renal interstitial fibrosis,and other ways.This article reviews the pharmacological effects and mechanisms of various small molecule drugs in the prevention and treatment of DKD,in order to provide ideas for early intervention or delay the treatment of progress of DKD and the combination of drugs.
small molecule drugdiabetic kidney diseasehemodynamicsanti-inflammationanti-oxidationanti-renal interstitial fibrosis
NETL
NSTL
万方数据
维普
