Research progress on interaction of transient receptor potential channels with Sigma-1 receptors and their regulation of pain
Transient receptor potential(TRP)channels are a kind of non-specific cation channel mainly residing at plasma membranes,which are sensors for a variety of cellular and environmental signals.Activated TRP channels are involved in various physiological and pathological processes by interacting with many physiological signal pathways.Sigma-1 receptor is a molecular chaperone protein that resides specifically in the mitochondria-associated endoplasmic reticulum membrane,and participated in the modulation of cell homeostasis and cell stress.There is interaction between TRP channels and Sigma-1 receptors,which is involved in regulating the occurrence and development of different types of pain.TRP channels and Sigma-1 receptors regulate capsaicin induced hyperalgesia,endogenous opioid peptide analgesic effects,oxaliplatin induced peripheral neuropathy,and peripheral immune driven hyperalgesia.This article summarizes the interaction between TRP channels and Sigma-1 receptors and their regulation of pain.
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