瞬时受体电位通道与Sigma-1受体相互作用及其调控疼痛的研究进展
Research progress on interaction of transient receptor potential channels with Sigma-1 receptors and their regulation of pain
王娅 1李瑞鑫 1葛朝明1
作者信息
- 1. 兰州大学第二医院 神经内科,甘肃 兰州 730030
- 折叠
摘要
瞬时受体电位(TRP)通道是一类主要定位于细胞膜的非特异性阳离子通道,是多种细胞和环境信号的传感器,激活后可与众多生理信号通路相互作用,参与多种生理病理过程.Sigma-1 受体是一种特异存在于线粒体相关内质网膜的分子伴侣蛋白,参与调控细胞稳态和细胞应激.TRP通道和Sigma-1 受体均广泛存在于哺乳动物体内各组织器官,研究发现二者之间存在相互作用,参与调节不同类型疼痛的发生、发展过程.TRP通道和Sigma-1 受体对辣椒素诱导的痛觉过敏、内源性阿片肽镇痛效应、奥沙利铂诱导的周围神经病变、外周免疫驱动的痛觉过敏进行调控.对TRP 通道与Sigma-1 受体的相互作用及其调控疼痛情况进行了总结.
Abstract
Transient receptor potential(TRP)channels are a kind of non-specific cation channel mainly residing at plasma membranes,which are sensors for a variety of cellular and environmental signals.Activated TRP channels are involved in various physiological and pathological processes by interacting with many physiological signal pathways.Sigma-1 receptor is a molecular chaperone protein that resides specifically in the mitochondria-associated endoplasmic reticulum membrane,and participated in the modulation of cell homeostasis and cell stress.There is interaction between TRP channels and Sigma-1 receptors,which is involved in regulating the occurrence and development of different types of pain.TRP channels and Sigma-1 receptors regulate capsaicin induced hyperalgesia,endogenous opioid peptide analgesic effects,oxaliplatin induced peripheral neuropathy,and peripheral immune driven hyperalgesia.This article summarizes the interaction between TRP channels and Sigma-1 receptors and their regulation of pain.
关键词
瞬时受体电位通道/Sigma-1受体/相互作用/痛觉过敏/镇痛效应/周围神经病变Key words
TRP channel/Sigma-1 receptor/interaction/hyperpathia/analgesic effect/peripheral neuropathy引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据