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抑制电导离子色谱法测定醋酸钙颗粒中钙离子

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目的 建立采用抑制电导离子色谱法测定醋酸钙颗粒中钙离子的方法。方法 采用Dionex IonPacTM CS12A色谱柱(250 mm×4 mm)，Dionex IonPacTM CG12A保护柱(50 mm×4 mm)，以 0。02 mol/L甲烷磺酸溶液为洗脱液，体积流量 1。0 mL/min，柱温 30℃，检测池温度 35℃，电导检测器，抑制器为Dionex CDRS 600 4 mm，电流值 59 mA，进样体积为 25 μL。结果 钙在 0。002～6。000 µg/mL线性关系良好(r=0。999 7)，平均回收率为 104。6%，RSD值为 1。8%。结论 方法简单、专属性高、准确可靠，能够有效地控制醋酸钙颗粒中钙离子。
Determination of calcium ion in Calcium Acetate Granules by ion chromatography-suppressed conductivity method
Objective To establish a method of ion chromatography-suppressed conductivity to determine calcium ion in Calcium Acetate Granules.Methods The assay was performed on Dionex IonPacTM CS12A column(250 mm×4 mm)with Dionex IonPacTM CG12A column(50 mm×4 mm)as guard column.Mobile phase was used as 0.02 mol/L methanesulfonic acid solution.Flow rate was 1.0 mL/min,column temperature was 30℃,and detecting pool temperature was 35℃.Conductivity detector was used with CDRS 600 4 mm as suppressor,current value was 59 mA,and injection volume was 25 μL.Results Calcium showed good linear relationships of 0.002—6.000 μg/mL(r=0.999 7),whose average recovery was 104.6% with RSD values of 1.8%.Conclusion The method is simple,highly specific,accurate and reliable,and can effectively control calcium ion in Calcium Acetate Granules.

Calcium Acetate Granulescalciumion chromatography-suppressed conductivity

葛薇薇、吴珺、朱静

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泰州市药品检验院,江苏 泰州 235500

醋酸钙颗粒 钙 抑制电导离子色谱法

2024

10.7501/j.issn.1674-5515.2024.02.012

现代药物与临床
天津药物研究院,中国药学会

现代药物与临床

CSTPCD
影响因子：1.179
ISSN：1674-5515
年,卷(期)：2024.39(2)
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