Clinical study on Xuezhikang Capsules combined with troxerutin in treatment of atherosclerotic thrombotic cerebral infarction
Objective To explore the clinical effect of Xuezhikang Capsules combined with troxerutin in treatment of atherosclerotic thrombotic cerebral infarction.Methods Patients(100 cases)with atherosclerotic thrombotic cerebral infarction in Nanyang Second General Hospital from September 2022 to September 2023 were divided into control group(50 cases)and treatment group(50 cases)according to random number table method.Patients in the control group were iv administered with Troxerutin Injection,360 mg added into normal saline 150 mL,once daily.Patients in the treatment group were po administered with Xuezhikang Capsules on the basis of the control group,2 grains/time,twice daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,Barthel and NIHSS scores,and the levels of LP-PLA2,HMGB1,ox-LDL,and VCAM-1 in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.00%,which was significantly higher than that of the control group(80.005%,P<0.05).After treatment,the improvement time of limb weakness,limb numbness,headache,dizziness and other symptoms in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,the Barthel index score in two groups was significantly increased,while the NIHSS score was significantly decreased(P<0.05),and the Barthel index and NIHSS score in the treatment group were significantly better than those in the control group(P<0.05).After treatment,the serum levels of LP-PLA2,HMGB1,ox-LDL,and VCAM-1 in two groups were significantly decreased(P<0.05),which in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion The synergistic treatment of troxerutin and Xuezhikang Capsules can effectively improve the clinical symptoms,restore the injury of brain nerve function and improve the ability of daily life.
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