Clinical study on Quantianma Capsules combined with nimodipine in treatment of migraine
Objective To investigate the clinical effect of Quantianma Capsules combined with Nimodipine Tablets in treatment of migraine.Methods Patients(88 cases)with migraine in Shanghai Songjiang District Sijing Hospital from February 2021 to April 2023 were divided into control and treatment groups according to the random number table method,and each group had 44 cases.Patients in the control group were po administered with Nimodipine Tablets,2 tablets/time,three times daily.Patients in the treatment group were po administered with Quantianma Capsules on the basis of the control group,6 grains/time,three times daily.Patients in two groups were treated for 12 weeks.After treatment,the clinical efficacies,migraine symptom,cerebral hemodynamic indexes,and serum indexes in two groups were compared.Results After treatment,the total effective rate of the treatment group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the frequency and duration of migraine attacks and VAS scores of two groups were lower than those before treatment(P<0.05),and the frequency and duration of migraine attacks and the VAS scores of the treatment group were lower than those of the control group(P<0.05).After treatment,the average blood flow velocity of anterior,middle,and posterior cerebral arteries was significantly decreased in two groups(P<0.05),and the average blood flow velocity of anterior,middle,and posterior cerebral arteries in the treatment group was lower than those in the control group(P<0.05).After treatment,the serum levels of MMP-9 in two groups were significantly decreased,but the serum levels of SP and β-EP in two groups were significantly increased(P<0.05).After treatment,the serum levels of MMP-9 in the treatment group was lower than those in the control group,but the serum levels of SP and β-EP in the treatment group were higher than those in the control group(P<0.05).Conclusion Quantianma Capsules combined with Nimodipine Tablets can improve the curative effect of migraine,can reduce the clinical effect,improve the level of cerebral hemodynamics,and improve serum indexes.
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