Clinical study on Jingwu Capsules combined with eszolam in treatment of insomnia of incompatibility between heart and kidney
Objective To explore the clinical effect of Jingwu Capsules combined with eszolam in treatment of insomnia of incompatibility between heart and kidney.Methods Patients(128 cases)with incompatibility between heart and kidney in Wuhan Hospital of Traditional Chinese Medicine from September 2021 to September 2023 were divided into control(64 cases)and treatment(64 cases)group by random numbers.Patients in the control group were po administered with Estazolam Tablets,1 mg/time,once daily.Patients in the treatment group were po administered with Jingwu Capsules on the basis of the control group,6 grains/time,three times daily.Patients in two groups were treated for 30 d.After treatment,the clinical evaluations was evaluated,the symptom relief time,PSQI scores,the levels of serological IL-1β,TNF-α,PGD2 and 5-HT,and adverse reaction in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.43%,which was significantly higher than that of the control group(84.38%,P<0.05).After treatment,the improvement time of difficulty falling asleep,shallow sleep,easy to wake up and difficulty falling asleep after waking in the treatment group was significantly shorter than that in the control group(P<0.05)..After treatment,the PSQI score in two groups was significantly decreased(P<0.05),and the PSQI score of the treatment group was significantly lower than that of the control group(P<0.05).After treatment,the serum levels of IL-1β and TNF-α were significantly decreased,while the levels of PGD2 and 5-HT were significantly increased in two groups(P<0.05),and the levels of these serum factors in the treatment group were significantly better than those in the control group(P<0.05).During the treatment,the incidence of adverse reactions in the control group was 12.57%,which was significantly higher than that in the treatment group(4.69%,P<0.05).Conclusion The synergistic treatment of eszolam and Jingwu Capsules is effective in improving clinical insomnia symptoms,and which effectively reduce the level of insomnia-related factors and significantly improve sleep quality.
Jingwu CapsulesEstazolam Tabletsincompatibility between heart and kidneyPSQIPGD25-HT
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