Clinical study on Xuanfei Zhisou Mixture combined with cefdinib in treatment of acute bacterial upper respiratory tract infection
Objective To explore the clinical effect of Xuanfei Zhisou Mixture combined with cefdinib in treatment of acute bacterial upper respiratory tract infection.Methods Patients(120 cases)with acute bacterial upper respiratory tract infection in Suzhou Jiulong Hospital of Shanghai Jiaotong University School of Medicine from June 2021 to June 2023 were randomly divided into control(60 cases)and treatment(60 cases)group.Patients in the control group were po administered with Cefdinir Dispersible Tablets,100 mg/time,three times daily.Patients in the treatment group were po administered with Xuanfei Zhisou Mixture on the basis of the control group,20 mL/time,three times daily.Patients in two groups were treated for 7 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,temperature(T),WBC,the levels of IL-6,PCT,CRP and IFN-γ in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.33%,which was significantly higher than that of the control group(83.33%,P<0.05).After treatment,the time of symptom improvement in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,the levels of T,WBC,IL-6,PCT and CRP in two groups were significantly lower than those before treatment,while the level of IFN-γ were significantly increased(P<0.05),and the levels of these indexes in the treatment group were significantly better than those in the control group(P<0.05).Conclusion The synergistic treatment of cefdinib and Xuanfei Zhisou Mixture can significantly improve the patient's body temperature and symptoms,and can effectively reduce the inflammatory state of the upper respiratory tract.
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