Clinical study on doxophylline combined with procaterol in treatment of acute attack of bronchial asthma
Objective To explore the clinical effect of doxophylline combined with procaterol in treatment of acute attack of bronchial asthma.Methods Patients(128 cases)with acute attack of bronchial asthma in Henan Province Chest Hospital from August 2021 to August 2023 were randomly divided into control(64 cases)and treatment(64 cases)group.Patients in the control group were iv administered with Doxofylline Injection,300 mg added into normal saline 100 mL,once daily.Patients in the treatment group were po administered with Procaterol Hydrochloride Granules on the basis of the control group,50 µg/time,three times daily.Patients in two groups were treated for 10 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,ACT scores,the levels of serum Cys-LTs,Eotaxin,IL-6 and PDGF-BB in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.44%,which was significantly higher than that of the control group(84.38%,P<0.05).After treatment,the recovery time of symptoms in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the ACT score in two groups was significantly higher than that before treatment(P<0.05),and the ACT score in the treatment group was significantly higher than that of the control group(P<0.05).After treatment,the serum levels of Cys-LTs,Eotaxin,IL-6 and PDGF-BB in two groups were significantly lower than those before treatment(P<0.05),and the levels in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion The combined treatment of procaterol and doxophylline can effectively improve the symptoms of asthma attack,enhance the ability of asthma control and reduce the content of local inflammatory factors.
Doxofylline InjectionProcaterol Hydrochloride Granulesacute episode of bronchial asthmaACTCys-LTsEotaxin
NETL
NSTL
万方数据
