Clinical study of Baikening Granules combined with budesonide in treatment of pertussis syndrome in children
Objective To explore the efficacy of Baikening Granules combined with budesonide in treatment of pertussis syndrome in children and its impact on tidal breathing lung function.Methods A total of 98 children with pertussis syndrome admitted to Hebei Children's Hospital from January 2020 to December 2022 were selected and divided into control group and treatment group by random number table method,with 49 cases in each group.Patients in the control group were given Budesonide Suspension for Inhalation,1 mL of Budesonide Suspension for Inhalation mixed with 2 mL of normal saline,twice daily.Patients in the treatment group were po administered with Baikening Granules on the basis of the control group,children≤1 year old,1 bag/time;1 year old<children≤3 years old,1.5 bags/time;children>3 years old,2 bags/time,3 times daily.Both groups were treated continuously for 10 d.The clinical effects of two groups were observed,and the changes of tidal respiratory lung function and serum interleukin 17(IL-17),interleukin 6(IL-6)and C-reactive protein(CRP)before and after treatment were compared between two groups.Results After treatment,the total effective rate of treatment group was 95.92%,which was significantly higher than that of control group(81.63%,P<0.05).After treatment,tidal volume per kilogram of body mass,peak-to-volume ratio and peak-to-time ratio in 2 groups were significantly increased compared with before treatment(P<0.05).After treatment,the tidal volume per kg of body mass,peak-to-volume ratio and peak-to-time ratio in treatment group were significantly higher than those in control group(P<0.05).After treatment,serum levels of IL-17,IL-6 and CRP in 2 groups were significantly lower than before treatment(P<0.05).After treatment,the serum levels of IL-17,IL-6 and CRP in treatment group were significantly lower than those in control group(P<0.05).In the course of treatment,the incidence of adverse reactions in control group and treatment group was 4.08% and 8.16%,respectively,and there was no statistical significance between the two groups.Conclusion Baikening Granules combined with budesonide is safe and effective in treatment of pertussis syndrome in children,and can obviously improve the moisture respiratory lung function and respiratory inflammatory response of children,which can be used as one of the options for clinical treatment of children with pertussis syndrome.
Baikening GranulesBudesonide Suspension for Inhalationpertussis syndrometidal volume in kilogramspeak volume ratiopeak time ratioIL-17CRP
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