Clinical study on Xingbei Zhike Grains combined with methylprednisolone in treatment of severe mycoplasma pneumonia in children
Objective To investigate the efficacy of Xingbei Zhike Grains combined with methylprednisolone in treatment of severe mycoplasma pneumonia in children.Methods A total of 90 children with severe mycoplasma pneumonia treated in Hefei Second People's Hospital from December 2018 to August 2023 were selected and divided into control group and treatment group according to random number table method,with 45 cases in each group.Children in the control group were iv administered with Methylprednisolone Sodium Succinate for injection,1.5 mg/kg for the first and second day,once daily,the dose was adjusted to 1 mg/kg from the third day.After that,the dose gradually decreased according to the children's condition within one week.Children in the treatment group were po administered with Xingbei Zhike Grains on the basis of the control group,1 bag/time,three times daily.Children in two groups were treated for 10 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,lung function indexes FVC,FEV1,PEF,levels of T-lymphocyte subsets CD4+and CD8+,serum levels of IL-6 and IL-1β in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group(95.56%)was significantly higher than that of the control group(77.78%,P<0.05).After treatment,compared with the control group,the disappearance time of lung wet rale and wheezing and the relief time of cough in the treatment group were significantly shorter than those in the control group(P<0.05).After treatment,FVC,FEV1 and PEF in children with severe mycoplasma pneumonia were significantly increased in two groups,and the above indexes increased more significantly in the treatment group(P<0.05).After treatment,the level of CD4+was significantly increased,while the levels of CD8+,IL-6 and IL-1β were significantly decreased in two groups(P<0.05),and the above indexes were improved more significantly in the treatment group(P<0.05).Conclusion Xingbei Zhike Granules combined with methylprednisolone is effective in the treatment of severe mycoplasma pneumonia in children,which can significantly shorten the improvement time of symptoms and signs,improve pulmonary function and immune disorder,and reduce inflammatory reaction.
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