Clinical study on Xiao'er Feike Granules combined with piperacillin sodium and tazobactam sodium in treatment of infantile bronchopneumonia
Objective To explore the clinical effect of Xiao'er Feike Granules combined with piperacillin sodium and tazobactam sodium in treatment of infantile bronchopneumonia.Methods Children(120 cases)with bronchopneumonia in Cangzhou People's Hospital from March 2021 to February 2023 were were divided into control group(60 cases)and treatment group(60 cases)according to random number table method.Children in the control group were iv administered with Piperacillin Sodium and Tazobactam Sodium for injection,3.375 g/time added into normal saline 100 mL,once daily.Children in the treatment group were po administered with Xiao'er Feike Granules on the basis of the control group,1 bag/time,three times daily.Children in two groups were treated for 7 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,the levels of WBC,NE,CRP,PCT,LDH and TNF-α,and adverse reactions in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group(98.33%)was significantly higher than that of the control group(83.33%,P<0.05).After treatment,the improvement time of lung rales,fever,shortness of breath and cough in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,the levels of WBC,NE,LDH,PCT,TNF-α and CRP in two groups were significantly lower than those before treatment(P<0.05),and these indexes in the treatment group were significantly lower than those in the control group(P<0.05).After treatment,the incidence of adverse reactions(5.01%)in the treatment group was significantly lower than that in the control group(13.33%,P<0.05).Conclusion Xiao'er Feike Granules combined with piperacillin sodium and tazobactam sodium in treatment of infantile bronchopneumonia is effective in improving symptoms such as pneumonia,cough,fever and other symptoms,which also can significantly restore liver function,and weaken pulmonary inflammatory reaction.
Xiao'er Feike GranulesPiperacillin Sodium and Tazobactam Sodium for injectioninfantile bronchopneumoniaWBCNEPCTCRP
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