Clinical study on Qingxuan Zhike Granules combined with methylprednisolone in treatment of refractory mycoplasma pneumonia in children
Objective To explore the clinical efficacy of Qingxuan Zhike Granules combined with Methylprednisolone Sodium Succinate for injection in treatment of refractory mycoplasma pneumonia in children.Methods Children(92 cases)with refractory mycoplasma pneumonia in Tianjin Union Medical Center from November 2022 to September 2023 were divided into control and treatment groups according to the computer random arrangement method,and each group had 46 cases.Children in the control group were iv administered with Methylprednisolone Sodium Succinate for injection,2 mg/kg daily.Children in the treatment group were po administered with Qingxuan Zhike Granules on the basis of the control group,3/4 bag each time for 4—6 years old,1 bag each time for 7 years old and above,three times daily.Children in two groups were treated for 7 d.After treatment,the clinical efficacies,symptom disappearance time,lung function,lung symptoms,and serum indicators in two groups were compared.Results After treatment,the total effective rate of the control group was 80.43%,and the total effective rate of the treatment group was 95.65%,with significant differences between the groups(P<0.05).After treatment,the disappearance times of fever,cough,sputum sounds,and wheezing in the treatment group was shorter than that in the control group(P<0.05).After treatment,the tidal volume,peak time ratio,and forced lung capacity of two groups were significantly increased(P<0.05),and the tidal volume,peak time ratio,and forced lung capacity of the treatment group were higher than those of the control group(P<0.05).After treatment,LUS score of two groups was smaller than that before treatment(P<0.05),and LUS score of the treatment group was smaller than that of the control group(P<0.05).After treatment,the serum levels of CRP,IL-25,TIM-3,and D-dimer in two groups were lower than those before treatment(P<0.05),and the serum levels of CRP,IL-25,TIM-3,and D-dimer in the treatment group were lower than those in the control group(P<0.05).Conclusion Qingxuan Zhike Granules combined with Methylprednisolone Sodium Succinate for injection can improve the efficacy of pediatric refractory mycoplasma pneumonia in children,improve lung function,and reduce clinical symptoms,lung symptoms,and inflammation.
Qingxuan Zhike GranulesMethylprednisolone Sodium Succinate for injectionrefractory mycoplasma pneumonia in childrendisappearance time of wheezingtidal volumepeak time ratioforced lung capacityLUS scoreCRPIL-25TIM-3D-dimer
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