Clinical observation of Jingling Mixture combined with methylphenidate in treatment of attention deficit hyperactivity disorder in children
Objective To investigate the clinical efficacy of Jingling Mixture combined with methylphenidate in treatment of attention deficit hyperactivity disorder in children.Methods A total of 88 children with attention deficit hyperactivity disorder diagnosed and treated in North District of Suzhou Municipal Hospital from January 2020 to December 2022 were selected,and all patients were divided into control group and treatment group according to random number table method,with 44 cases in each group.Children in the control group were po administered with Methylphenidate Hydrochloride Prolonged-Release Tablets,and the initial dosage was 18 mg/time,and if the efficacy was not good,the dosage was increased by 18 mg to 36 mg daily,once daily,and the whole tablet was taken with warm water.Patients in the treatment group were po administered with Jingling Mixture on the basis of the control group,6 years old<children≤9 years old,6—9 mL/time;9 years old<children≤12 years old,10 mL/time,twice daily.The treatment course of both groups was 12 weeks.The efficacy of two groups was observed.The improvement time of core symptoms was compared between two groups.And Swanson before and after treatment,Nolan and Pelham Parent Rating Scale(SNAP)-Ⅳ,Conners Parent Symptom Questionnaire(PSQ),Child Difficulty Questionnaire(QCD),Weiss Functional Impairment Scale(Parent version)(WFIRS-P),Strengths and Difficulties Questionnaire(SDQ),Achenbach Child Behavior Scale(CBCL)scores before and after treatment were compared between two groups.Results After treatment,the total effective rate of treatment group was 95.45%,which was significantly higher than that of control group(81.82%)(P<0.05).After treatment,the improvement time of hyperactivity,attention deficit and impulsivity in the treatment group was significantly shorter than that in control group(P<0.05).After treatment,attention deficit score,hyperactivity-impulse score,oppositional defiant score and total score were significantly decreased in both groups compared with before treatment(P<0.05).After treatment,SNAP-Ⅳ scores in treatment group were significantly lower than those in control group(P<0.05).After treatment,PSQ,WFIRS-P,SDQ and CBCL scores were significantly decreased,but QCD scores were significantly increased in both groups(P<0.05).After treatment,the scores of PSQ,WFIRS-P,SDQ,CBCL and QCD in treatment group were better than those in control group(P<0.05).Conclusion Jingling Mixture combined with methylphenidate has accurate overall effect in treatment of attention deficit hyperactivity disorder in children,and can effectively accelerate the improvement of core symptoms,reduce functional impairment,emotional and behavioral problems,which is worthy of clinical application.
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