Clinical study of Anluo Huaxian Pills combined with tiopronin in treatment of liver cirrhosis caused by chronic hepatitis B
Objective To explore the clinical efficacy of Anluo Huaxian Pills combined with tiopronin in treatment of liver cirrhosis caused by chronic hepatitis B.Methods A total of 166 patients with chronic hepatitis B cirrhosis admitted to Xi'an Eighth Hospital from August 2021 to February 2023 were selected and divided into control group and treatment group according to random number table method,with 83 cases in each group.Patients in the control group were iv administered with Tiopronin for injection,0.2 g was added into 0.9% sodium chloride injection 250 mL for full dilution and administration,once daily.Patients in the treatment group were po administered with Anluo Huaxian Pills on the basis of the control group,6 g/time,twice daily.The treatment course of both groups was 3 months.After treatment,the clinical efficacy was evaluated,and the liver function indexes[alanine transaminase(ALT),total bilirubin(TBiL),albumin to globulin ratio(A/G)],aspartate Transaminase to platelet(PLT)ratio index(APRI)score,liver hardness measurement(LSM)value,and liver/spleen CT value ratio were compared between the two groups before and after treatment.The levels of serum hepatic fibrosis markers[type Ⅲ procollagen N-terminal peptide(PC-Ⅲ),hyaluronic acid(HA),type Ⅳ collagen(Ⅳ-C),Laminin(LN)],High-mobility group protein B1(HMGB1),interleukin-17(IL-17),soluble P Selectin(sP selectin)]were also measured.Results After treatment,the total effective rate of the treatment group was 90.36%,which was significantly higher than that of control group(78.31%,P<0.05).After treatment,serum ALT and TBiL levels were significantly decreased,but A/G were significantly increased in both groups(P<0.05).After treatment,the improvement of liver function indexes in treatment group was better than that in control group(P<0.05).After treatment,APRI score and LSM value were significantly decreased,and the ratio of liver/spleen CT value was significantly increased in both groups(P<0.05).The improvement was more significant in treatment group(P<0.05).After treatment,the serum levels of PC-Ⅲ,HA,Ⅳ-C and LN in 2 groups were significantly decreased(P<0.05).The improvement was more significant in treatment group(P<0.05).After treatment,serum HMGB1,IL-17 and sP-selectin levels in 2 groups were significantly decreased(P<0.05).After treatment,the levels of HMGB1,IL-17 and sP-selectin in treatment group were lower than those in control group(P<0.05).Conclusion Anluo Huaxian Pills combined with tiopronin can effectively improve the curative effect in treatment of liver cirrhosis caused by chronic hepatitis B,and can improve liver function and liver fibrosis,inhibit the process of chronic inflammation and cirrhosis of the body with good safety,which is worthy of clinical promotion.
Anluo Huaxian PillsTiopronin for injectionliver cirrhosis caused by chronic hepatitis Binflammatory responsesP-selectin
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