Clinical observation on Mulberry Twig Alkaloids Tablets combined with insulin degludec and insulin aspart in treatment of type 2 diabetes mellitus
Objective To explore clinical effect of Mulberry Twig Alkaloids Tablets combined with Insulin Degludec and Insulin Aspart Injection in treatment of type 2 diabetes mellitus.Methods Patients(108 cases)with type 2 diabetes mellitus in Xing'an League People's Hospital from January 2021 to December 2022 were divided into control and treatment groups according to the random number table method,and each group had 54 cases.Patients in the control group were sc injected with Insulin Degludec and Insulin Aspart Injection,once daily,taking the medicine with the largest meal of the day.Patients in the treatment group were po administered with Mulberry Twig Alkaloids Tablets on the basis of the control group,1 tablets/time,three times daily,after chewing,taking it together with the first bite or first few bites of food.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies,blood glucose index,blood glucose fluctuation index,and insulin function index in two groups were compared.Results After treatment,the total effective rate of treatment group and control group was 94.44% and 81.48%,respectively,and the difference between groups was statistically significant(P<0.05).After treatment,FPG,2 h PG,HbAlc,SDBG,MODD,and MAGE in two groups were lower than those before treatment(P<0.05),and FPG,2 h PG,HbAlc,SDBG,MODD,and MAGE in treatment group were lower than those in the control group(P<0.05).After treatment,FINS and HOMA-β in two groups were significantly increased,but HOMA-IR in two groups was significantly decreased(P<0.05),and FINS and HOMA-β in the treatment group were significantly higher than those in the control group,while HOMA-IR in the treatment group was lower than that in the control group(P<0.05).Conclusion Mulberry Twig Alkaloids Tablets combined with Insulin Degludec and Insulin Aspart Injection has a definite clinical effect in treatment of type 2 diabetes mellitus,can significantly reduce blood sugar in patients,reduce blood sugar fluctuations,improve islet β cell function and insulin resistance.
Mulberry Twig Alkaloids TabletsInsulin Degludec and Insulin Aspart Injectiontype 2 diabetes mellitusFPG2 h PGHbAlcSDBGMODDMAGEFINSHOMA-βHOMA-IR
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