Clinical study on Pudilan Xiaoyan Oral Liquid combined with hydroxychloroquine in treatment of oral lichen planus
Objective To investigate the effect of Pudilan Xiaoyan Oral Liquid combined with Hydroxychloroquine Sulfate Tablets in treatment of oral lichen planus.Methods Patients(82 cases)with oral lichen planus in Tangshan People's Hospital from November 2020 to June 2023 were divided into control and treatment groups according to the random number table method,and each group had 41 cases.Patients in the control group were po administered with Hydroxychloroquine Sulfate Tablets,1 tablets/time,twice daily.Patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group,10 mL/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies,the physical signs score,NRS scores,lesion area,and serum indexes in two groups were compared.Results After treatment,the total effective rate of the treatment group(92.68%)was significantly higher than that of the control group(75.61%),and the difference was statistically significant(P<0.05).After treatment,the physical signs score,NRS score,and lesion area were significantly lower than those before treatment(P<0.05),and the physical signs score,NRS score,and lesion area of the treatment group were lower than those of the control group(P<0.05).After treatment,the serum levels of IL-17,NGF,and IL-12 in two groups were lower than those before treatment(P<0.05),and the serum levels of IL-17,NGF,and IL-12 in the treatment group were lower than those in the control group(P<0.05).Conclusion Pudilan Xiaoyan Oral Liquid combined with Hydroxychloroquine Sulfate Tablets can improve the therapeutic effect of oral lichen planus,reduce symptoms and signs,reduce the area of lesion,and reduce inflammation.
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