Clinical study on Eucalyptol,Limonene and Pinene Enteric Soft Capsules combined with amphotericin B in treatment of fungal sinusitis
Objective To explore the treatment effect of Eucalyptol,Limonene and Pinene Enteric Soft Capsules combined with amphotericin B in treatment of fungal sinusitis.Methods Patients(112 cases)with fungal sinusitis in Qingdao Chengyang People's Hospital from July 2021 to July 2023 were randomly divided into control(56 cases)and treatment(56 cases)group.Patients in the control group were iv administered with Amphotericin B for injection,25 mg added into normal saline 100 mL,once every 2 d.Patients in the treatment group were po administered with Eucalyptol,Limonene and Pinene Enteric Soft Capsules on the basis of the control group,0.3 g/time,three times daily.Patients in two groups were treated for 14 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,SF-36 scores,the levels of serological IL-17,TNF-α,Dectin-1 and INF-γ,and adverse reactions in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 98.21%,which was significantly higher than that of the control group(82.14%,P<0.05).After treatment,the time of symptom relief in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the scores of RP,SF,RE and CH in two groups were significantly higher than those before treatment(P<0.05),and the scores in the treatment group were significantly higher than those in the control group(P<0.05).After treatment,the levels of serum factors IL-17,TNF-α and Dectin-1 in two groups were significantly decreased,while the level of INF-γ was significantly increased(P<0.05),and the level of serum factors in the treatment group was significantly better than that in the control group(P<0.05).After treatment,the incidence of adverse reactions in the control group was 14.20%,which was significantly higher than that in the treatment group(3.57%,P<0.05).Conclusion Amphotericin B combined with Eucalyptol,Limonene and Pinene Enteric Soft Capsules in treatment of fungal sinusitis can improve clinical symptoms,reduce the state of nasal sinus inflammation and improve the quality of life.
Eucalyptol,Limonene and Pinene Enteric Soft CapsulesAmphotericin B for injectionfungal sinusitisSF-36Dectin-1TNF-α
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