Clinical study of Shihu Yeguang Pills combined with Polyethylene Glycol Eye Drops in treatment of dry eyes
Objective To analyze the clinical efficacy of Shihu Yeguang Pills combined with Polyethylene Glycol Eye Drops in treatment of dry eyes.Methods A total of 136 patients with dry eye treated in the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from June 2022 to June 2023 were selected and divided into control group and treatment group according to random number table method,with 68 cases in each group.Patients in control group were given Polyethylene Glycol Eye Drops,shook well before use,1 drop/eye,3 times daily.Patients in the treatment group were po administered with Shihu Yeguang Pills on the basis of the control group,1 pill/time,twice daily.Both groups were treated for 4 weeks.The clinical efficacy,fluorescein stained tear film break time(FBUT)and other relevant clinical examination indicators,OSDI scores,DEQS scores,DASS-21 scores,TGF-β2,CCL1,sST2,and IL-1β were compared in two groups before and after treatment were compared.Results After treatment,the total effective rate of the treatment group was 97.06%,which was significantly higher than that of the control group(88.24%,P<0.05).After treatment,FBUT,SⅠt and lacrimal river height were significantly increased,while FL scores were significantly decreased in both groups(P<0.05).After treatment,the improvement of relevant clinical examination indexes in the treatment group was better than that in the control group(P<0.05).After treatment,OSDI score,DEQS score and DASS-21 score were significantly decreased in both groups(P<0.05).After treatment,OSDI score,DEQS score and DASS-21 score in treatment group were significantly lower than those in control group(P<0.05).After treatment,the levels of TGF-β2 in tears of both groups were significantly increased,but the levels of CCL1,sST2 and IL-1β in tears were significantly decreased(P<0.05).After treatment,the improvement of TGF-β2,CCL1,sST2 and IL-1β in tears of the treatment group was better than that of control group(P<0.05).Conclusion Shihu Yeguang Pills combined with Polyethylene Glycol Eye Drops has definite curative effects in treatment of dry eyes,and can safely and effectively control dry eye,promote the alleviation of ocular inflammation and ocular surface damage,further improve the stability of tear film and tear secretion function of patients,improve the quality of life and mental state,which is worthy of clinical promotion and application.
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