Clinical study on Nuangong Yunzi Pills combined with ethinylestradiol and cyproterone acetate in treatment of infertility caused by polycystic ovary syndrome
Objective To investigate the efficacy of Nuangong Yunzi Pills combined with ethinylestradiol and cyproterone acetate in treatment of infertility caused by polycystic ovary syndrome.Methods A total of 88 infertility patients with polycystic ovary syndrome treated in Bozhou People's Hospital from January 2021 to September 2022 were selected and divided into control group(44 cases)and treatment group(44 cases)by random number table method.Patients in the control group were po administered with Ethinylestradiol and Cyproterone Acetate Tablets on the fifth day of menstruation,1 tablet/d,21 days of medicine as a course of treatment,and then stopped until the fifth day of the next menstruation to start the next course,the treatment was a total of 3 courses.Patients in the treatment group were po administered with Nuangong Yunzi Pills on the basis of the control group from the fifth day of menstruation,8 pills/time,three times daily,12 days of medicine as a course of treatment,and then stopped until the fifth day of the next menstruation to start the next course,the treatment was a total of 3 courses.After treatment,the clinical evaluations were evaluated,the traditional Chinese medicine(TCM)syndrome scores,the levels of hormone LH,T and LH/FSH,and natural pregnancy rate and early abortion rate in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 93.18%,which was significantly higher than that of the control group(77.27%,P<0.05).After treatment,the scores of lumbar sore legs and soft legs,fear of cold and cold limbs in two groups were significantly decreased(P<0.05),and the decrease in the treatment group was significantly higher than that in the control group(P<0.05).After treatment,the levels of LH,T and FSH in two groups were significantly decreased,and the decrease in the treatment group was greater than that in the control group(P<0.05).After treatment,the natural pregnancy rate in the treatment group was significantly higher than that in the control group(P<0.05).Conclusion Nuangong Yunzi Pills combined with ethinylestradiol and cyproterone acetate has a good clinical effect in treatment of infertility caused by polycystic ovary syndrome,which can improve the clinical symptoms and hormone levels and increase the natural pregnancy rate.
Nuangong Yunzi PillsEthinylestradiol and Cyproterone Acetate Tabletspolycystic ovary syndromeinfertilitygestationtraditional Chinese medicine syndrome scoresLH
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