Clinical study on Guizhi Fuling Pills combined with ethinylestradiol and cyproterone acetate in treatment of adenomyopathy
Objective To investigate the clinical effect of Guizhi Fuling Pills combined with Ethinylestradiol and Cyproterone Acetate Tablets in treatment of adenomyopathy.Methods Women(94 cases)with adenomyopathy in the First Affiliated Hospital of Hebei North University from June 2021 to March 2023 were divided into control and treatment groups according to the random number table method,and each group had 47 cases.Women in the control group were po administered with Ethinylestradiol and Cyproterone Acetate Tablets,1 tablet/time,once daily,continuous treatment for 21 d,taking one month as one course of treatment,and continuously treated for six months.Women in the treatment group were po administered with Guizhi Fuling Pills on the basis of the control group,1 pill/time,once daily,continuously treated for six months.After treatment,the clinical efficacies,dysmenorrhea degree,ultrasound index,coagulation index,and serum factor level in two groups were compared.Results After treatment,the total effective rate of the treatment group was 95.74%,which was significantly higher than that of the control group(82.98%),and the difference between groups was significant(P<0.05).After treatment,VAS score,uterine volume,and endometrial thickness of two groups were lower than those before treatment(P<0.05),and VAS score,uterine volume,and endometrial thickness of the treatment group were smaller than those of the control group(P<0.05).After treatment,FIB,INR,PT,and serum levels of IGF-1,CXCL-12,and EMAb in two groups were lower than those before treatment(P<0.05),and FIB,INR,PT,and serum levels of IGF-1,CXCL-12,and EMAb in the treatment group were lower than those in the control group(P<0.05).Conclusion Guizhi Fuling Pills combined with Ethinylestradiol and Cyproterone Acetate Tablets can improve the efficacy of adenomyopathy,reduce the dysmenorrhea degree,reduce uterine volume,improve coagulation function,and reduce serum factor level.
Guizhi Fuling PillsEthinylestradiol and Cyproterone Acetate TabletsadenomyopathyVAS scoreuterine volumeendometrial thicknessFIBINRPTIGF-1CXCL-12EMAb
NETL
NSTL
万方数据
