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盐酸罂粟碱注射液应用合理性评价

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目的 建立盐酸罂粟碱注射液合理性评价标准,评价盐酸罂粟碱注射液临床使用合理性。方法 以盐酸罂粟碱注射液说明书、国内外指南及专家共识为基础制定合理性评价标准,对亳州市人民医院 2023 年1~12 月 260 例患者使用盐酸罂粟碱注射液的出院病历进行评价。结果 260 例病历中,合理(Ci≥0。8)84 例(32。31%),基本合理(0。6≤Ci<0。8)67例(25。77%),不合理(Ci<0。6)病历 109 例(41。92%)。主要不合理问题表现为无适应证用药 73 例(28。08%)、用法用量不适宜 86 例(33。08%)、使用疗程过长 31 例(11。92%)、溶媒选择不适宜 9 例(3。46%)和药物相互作用 129 例(49。62%)等。结论 基于加权TOPSIS法评价盐酸罂粟碱注射液是切实可行的,结果表明亳州市人民医院存在一些不合理使用现象,医院应加强不合理用药管理力度,确保临床合理用药。
Evaluation of application rationality of Papaverine Hydrochloride Injection
Objective To establish the rationality evaluation criteria of Papaverine Hydrochloride Injection,and evaluate the rationality of the clinical use of Papaverine Hydrochloride Injection.Methods Based on the instructions for Papaverine Hydrochloride Injection,domestic and international guidelines,and expert consensus,the rationality evaluation standard was developed to evaluate the discharge medical records of 260 patients using Papaverine Hydrochloride Injection in Bozhou People's Hospital from January to December 2023.Results Among the 260 medical records,84 cases(32.31%)were reasonable(Ci≥0.8),67 cases(25.77%)were basically reasonable(0.6≤Ci<0.8),and 109 cases(41.92%)were unreasonable(Ci<0.6).The main unreasonable problems were manifested in 73 cases(28.08%)of medication without indication,86 cases(33.08%)of inappropriate dosage,31 cases(11.92%)of excessive use of treatment course,9 cases(3.46%)of inappropriate choice of solvent,and 129 cases(49.62%)of drug interactions.Conclusion It is feasible to evaluate Papaverine Hydrochloride Injection based on the weighted TOPSIS method,and the results indicate that there are more unreasonable uses in Bozhou People's Hospital.The hospital should strengthen the management of unreasonable use of drugs to ensure rational use in clinic.

Papaverine Hydrochloride Injectionweighted TOPSIS methodevaluation criteriarational drug usemedication without indicationinappropriate dosage

马蒙、孙丹丹、过之一、梁海、董训忠

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亳州市人民医院 药学部,安徽 亳州 236800

亳州市人民医院 血管外科,安徽 亳州 236800

盐酸罂粟碱注射液 加权TOPSIS法 评价标准 合理用药 无适应证用药 用法用量不适宜

亳州市卫生健康科研重点项目

bzwj2022a002

2024

现代药物与临床
天津药物研究院,中国药学会

现代药物与临床

CSTPCD
影响因子:1.179
ISSN:1674-5515
年,卷(期):2024.39(2)
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