Research progress on drugs in treatment of metal-producing β-lactamase bacteria
Metal β-lactamases belong to class B β-lactamases,and can extensively hydrolyze all β-lactam antibiotics except for monocyclic antibiotics.Metal-producing β-lactamase strains often exhibit multiple drug resistance,increasing the difficulty of clinical anti-infection treatment.Drugs in treatment of metal-producing β-lactamase bacteria mainly include combination drug based on amtreonam,cefiderocol,novel drugs β-lactam combination with β-lactamase inhibitors,and newly developed antibiotics based on traditional antibiotic structures.Therefore,this article summarizes research progress on drugs in treatment of metal-producing β-lactamase bacteria,to provide references for clinical treatment of bacterial infections caused by metal-producing β-lactamase bacteria.
metal-producing β-lactamasemultiple drug resistanceamtreonamcefiderocolβ-lactamase inhibitornew antibiotic
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