首页|通心络胶囊治疗冠状动脉微血管病的临床疗效及其作用机制研究进展

通心络胶囊治疗冠状动脉微血管病的临床疗效及其作用机制研究进展

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冠状动脉微血管病是诸多心血管事件的高风险因素，发病率高，诊断率低，病因复杂，并且现代医学尚缺乏针对冠状动脉微血管病的特效治疗药物。通心络胶囊被广泛用于治疗微血管性心绞痛、心脏 X 综合征、经皮冠状动脉介入治疗术后心绞痛、冠状动脉无复流、冠状动脉慢血流，其作用机制与保护冠状动脉微血管内皮细胞、改善血管内皮功能、抑制炎症反应、改善冠状动脉微循环等途径密切相关。总结了通心络胶囊治疗不同类型冠状动脉微血管病的临床疗效及其作用机制的研究进展，以期为通心络胶囊的临床应用和冠状动脉微血管病的治疗提供参考。
Research progress on clinical effect and mechanism of action of Tongxinluo Capsules in treatment of coronary microvascular disease
Coronary microvascular disease is a high risk factor for many cardiovascular events,with high incidence rate,low diagnostic rate and complex etiology.Modern medicine still lacks specific therapeutic drugs for coronary microvascular disease.Tongxinluo Capsules are widely used in treatment of microvascular angina,cardiac syndrome X,postoperative angina after percutaneous coronary intervention(PCI),coronary artery no reflow,and slow coronary flow.Its mechanism of action is closely related to the protection of coronary microvascular endothelial cells,improvement of endothelial function,inhibition of inflammatory response,and improvement of coronary microcirculation.This article summarizes the clinical efficacy and mechanism of action of Tongxinluo Capsules in treatment of different types of coronary microvascular diseases,providing reference for the clinical application of Tongxinluo Capsules and the treatment of coronary microvascular diseases.

Tongxinluo Capsulescoronary microvascular diseasemicrovascular anginacardiac syndrome Xslow coronary flowendothelial functioninflammatory responsecoronary microcirculation

郭流漓、杨昊霖、杨志华、李真真、王淑萍

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天津中医药大学,天津 301617

武警特色医学中心,天津 300162

通心络胶囊 冠状动脉微血管病 微血管性心绞痛 心脏X综合征 冠状动脉慢血流 血管内皮功能 炎症反应 冠状动脉微循环

天津市研究生科研创新项目天津中医药大学研究生科研创新项目

2021YJSB294YJSKC-20211012

2024

10.7501/j.issn.1674-5515.2024.02.044

现代药物与临床
天津药物研究院,中国药学会

现代药物与临床

CSTPCD
影响因子：1.179
ISSN：1674-5515
年,卷(期)：2024.39(2)
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