Research progress on pharmacological effects of curcumin in prevention and treatment of heart failure
Heart failure is a common end-stage clinical manifestation of various cardiovascular events,such as hypertension,ischemic heart disease,valvular heart disease,and coronary heart disease.Its pathological features are mainly progressive cardiac insufficiency and myocardial remodeling.Curcumin can inhibit myocardial hypertrophy and fibrosis,enhance autophagy,reduce oxidative stress,alleviate myocardial inflammatory damage,regulate Ca2+-ATP ase activity,up-regulate DKK-3 expression,prevent and treat heart failure in multiple ways,further prevent myocardial remodeling,and improve cardiac function.This article summarizes the research progress of curcumin in prevention and treatment of heart failure,analyzes its mechanism of action,and provides support for the clinical application of curcumin.
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