Mechanism of Shuganning Injection in treatment of hepatitis B based on network pharmacology
Objective To explore the mechanism of Shuganning Injection in treatment of hepatitis B by using network pharmacology and molecular docking.Methods Nineteen representative chemical components of Shuganing Injection were selected as research objects,and the potential target of the compound was obtained through TCMSP and Swiss Target Prediction database.DisGeNET and GeneCards databases were used to retrieve disease-related targets of viral hepatitis B,and the intersection targets of compound and disease targets were obtained by Venny platform as potential targets of Shuganing Injection in treatment of viral hepatitis B.PPI network analysis,Cluster module analysis,GO,KEGG analysis were further performed for target proteins.On the basis of PPI core target network analysis,the network pharmacological results were further verified by molecular docking method.Results 173 Potential targets of Shuganing Injection from 19 components were obtained for the treatment of viral hepatitis B,and it could act on SRC,HSP90AA1,ERS1,PIK3CA,HRAS,and other core targets,and regulate the signaling pathways of viral hepatitis B,viral hepatitis C,VEGF,TNF,PI3K/Akt,etc.The results of molecular docking showed that the active ingredients associated with the signaling pathway of Shuganing Injection and viral hepatitis B could spontaneously bind to related targets.Conclusion The mechanism of Shuganing Injection in treatment of viral hepatitis B may be through multi-component and multi-target intervention of hepatitis B signaling pathway.
NETL
NSTL
万方数据
