Single crystal culture and its structure characterization of methyl(S)-2-(tert-butoxycarbonyl)amino-3-[(S)-2-oxopyrrolidin-3-yl]propanoate
Objective To cultivate the single crystal and perform crystal morphology characterization and stereo-structural confirmation of methyl(S)-2-(tert-butoxycarbonyl)amino-3-[(S)-2-oxopyrrolidin-3-yl]propanoate.Methods The single crystals were cultivated with of ethyl acetate-methyl tert-butyl ether(1∶1)solvent system,and TGA,DSC,XRPD,and SXRD were used to analyze.Results Nice colorless bulk crystals were obtained with approximately 114℃of melting point.The crystal cell belongs to an orthogonal crystal system,with a spatial group of P212121.Molecular formula was C13H22N2O5,molecular weight was 286.33,crystal density was 1.152 mg/mm3,and an absolute configuration was S,S style.Conclusion The stereo-configuration of methyl(S)-2-(tert-butoxycarbonyl)amino-3-[(S)-2-oxopyrrolidin-3-yl]propanoate has been confirmed,and the cultured crystals are non-hydrated and solvated.
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