Clinical study of Naoan Dropping Pills combined with butylphthalide in treatment of acute cerebral infarction
Objective To explore the clinical efficacy of Naoan Dropping Pills combined with butylphthalide in treatment of acute cerebral infarction.Methods A total of 146 patients with acute cerebral infarction admitted to Beijing Longfu Hospital from January to December 2022 were selected and divided into control group and treatment group according to random number table method,with 73 patients in each group.Patients in the control group were iv administered with Butylphthalide and Sodium Chloride Injection,100 mL/time,twice daily,infusion time≥50 min/time.Patients in the treatment group were po administered with Naoan Dropping Pills on the basis of the control group,20 pills/time,twice daily.Patients in two groups were treated for 14 d.After treatment,the clinical efficacy was evaluated,and the scores of the simplified Fugl Meyer Rating Scale(FMA)and the National Institutes of Health Stroke Scale(NIHSS),the parameters of thrombus and platelet,and the levels of serum C-reactive protein(CRP),nitric oxide(NO),superoxide dismutase(SOD),glutamic acid(Glu)were compared between the two groups before and after treatment.Results After treatment,the total effective rate of the treatment group was 95.89%,which was significantly higher than that of the control group(86.30%,P＜0.05).After treatment,FMA score in both groups was significantly higher than before treatment,but NIHSS score was significantly lower(P＜0.05).FMA and NIHSS scores in the treatment group were significantly improved(P＜0.05).After treatment,plasma plasminase-anti-plasminase complex(PAP),thrombin antithrombin complex(TAT)and platelet aggregation rate(PAgT)in two groups were significantly decreased compared with before treatment(P＜0.05).The decrease was more significant in the treatment group(P＜0.05).After treatment,serum CRP and Glu levels were significantly decreased,while serum NO and SOD levels were significantly increased in two groups(P＜0.05).The serum levels of CRP,NO,SOD and Glu in the treatment group were significantly improved(P＜0.05).Conclusion Naoan Dropping Pills combined with butylphthalide has good therapeutic effect in treatment of acute cerebral infarction,and can safely and effectively anti-thrombosis,relieve inflammation and oxidative stress damage,promote the improvement of nerve and motor function.
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