Clinical study of Naodesheng Pills combined with agatroban in treatment of acute cerebral infarction
Objective To explore the clinical efficacy of Naodesheng Pills combined with agatroban in treatment of acute cerebral infarction.Methods A total of 106 patients with acute cerebral infarction admitted to Xinhua Hospital of Xinhua Medical Group in Huainan from January 2021 to December 2022 were selected and divided into control group and treatment group according to random number table method,with 53 patients in each group.Patients in the control group were iv administered with Argatroban Injection,the drug was injected intravenously at a rate of 2.5 mg/h for 48 h.Then the dosage was adjusted to 10 mg/time,each time at an interval of 12 h,each administration time≥3 h,5 d.The total treatment time of agatroban was 7 d,and the conventional symptomatic treatment was continued after the end of the treatment.Patients in the treatment group were po administered with Naodesheng Pills on the basis of the control group,2 g/time,three times daily.The two groups were treated continuously for 14 d.The clinical effects of the two groups were observed,and the neurological defects,thromboelastogram indexes and coagulation function indexes were compared before and after treatment.Results After treatment,the total effective rate of treatment group was 94.34%,which was significantly higher than that of control group(81.13%,P＜0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)scores of the two groups were significantly lower than before treatment(P＜0.05),and the NIHSS scores of treatment group were lower than those of control group after 3,7 and 14 days of treatment(P＜0.05).After treatment,the coagulation Angle(Angle),coagulation composite index(CI)and maximum thrombus intensity(MA)in 2 groups were significantly decreased compared with before treatment,but coagulation reaction time(R)was increased(P＜0.05).After treatment,Angle,CI and MA in the treatment group were lower than those in control group,while R value was higher than that in control group(P＜0.05).After treatment,fibrinogen(FIB),D-dimer(D-D)and fibrin degradation product(FDP)in 2 groups were significantly decreased compared with before treatment,but antithrombinⅢ(AT-Ⅲ)was significantly increased(P＜0.05).After treatment,FIB,D-D and FDP in treatment group were lower than those in control group,while AT-Ⅲ was higher than that in the control group(P＜0.05).Conclusion Naodesheng Pills combined with agatroban can achieve better results in treatment of acute cerebral infarction,and can effectively reverse the hypercoagulable state in patients and inhibit thrombosis,has a very important role in alleviating nerve damage with good safety,which is worthy of clinical application.
Naodesheng PillsArgatroban Injectionacute cerebral infarctionNIHSS scoreAngleCIMAcoagulation function
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