Clinical study on sodium oligomannate combined with galantamine in treatment of vascular dementia
Objective To explore the clinical effect of sodium oligomannate combined with galantamine in treatment of vascular dementia.Methods Patients(100 cases)with vascular dementia in Shanghai Baoshan Luodian Hospital from July 2021 to June 2023 were randomly divided into control(50 cases)and treatment(50 cases)group.Patients in the control group were iv administered with Galantamine Hydrobromide Injection,2 mg/time,twice daily.Patients in the treatment group were po administered with Sodium Oligomannate Capsules on the basis of the control group,3 grains/time,twice daily.Patients in two groups were treated for 28 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,the scores of ADL and MMSE,the levels of serum IL-1β,Lp-PLA2,SOD and BDNF in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 88.00%,which was significantly higher than that of the control group(70.005%,P＜0.05).After treatment,the time of symptom improvement in the treatment group was significantly earlier than that in the control group(P＜0.05).After treatment,the ADL score in two groups was significantly decreased,while the MMSE score was significantly increased(P＜0.05),and the ADL and MMSE scores in the treatment group were significantly better than those of the control group(P＜0.05).After treatment,the levels of serum inflammatory factors IL-1β and Lp-PLA2 were significantly decreased,while the levels of SOD and BDNF were significantly increased in two groups(P＜0.05),and the level of serum inflammatory factors in the treatment group were significantly better than that in the control group(P＜0.05).Conclusion The synergistic treatment of galantamine and sodium oligomannate can significantly alleviate clinical symptoms,which can effectively reduce the inflammatory response state,effectively enhance daily living ability.
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