Clinical study on Danxiang Guanxin Injection combined with ticagrelor tablets in treatment of acute myocardial infarction
Objective To investigate the clinical effect of Danxiang Guanxin Injection combined with Ticagrelor Tablets in treatment of acute myocardial infarction.Methods Patients(95 cases)with acute myocardial infarction in Beijing Luhe Hospital,Capital Medical University from February 2019 to May 2023 were divided into control(47 cases)and treatment(48 cases)group according to the different treatments.Patients in the control group were po administered with Ticagrelor Tablets,90 mg/time,twice daily.Patients in the treatment group were iv administered with Danxiang Guanxin Injection on the basis of the control group,20 mL added into 5%glucose injection 250 mL,once daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical evaluations were evaluated,the levels of LVESD,LVEF,CI,CO,E/A,LVPWT,IVST,LVM,MPO,SAA1 and sST2 in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 89.58%,which was significantly higher than that of the control group(70.21%,P＜0.05).After treatment,the levels of LVESD,LVPWT,IVST,MPO,SAA1,and sST2 were significantly decreased,while LVEF,CI,CO,E/A,and LVMI were significantly increased in two groups(P＜0.05),and the level of these indexes in the treatment group was significantly better than that in the control group(P＜0.05).Conclusion Danxiang Guanxin Injection combined with Ticagrelor Tablets can significantly improve the clinical effective rate of acute myocardial infarction,improve myocardial function and reverse ventricular remodeling,and reduce myocardial injury and inflammation.
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