Clinical study on Di'ao Xinxuekang Capsules combined with atorvastatin in treatment of stable angina pectoris
Objective To explore the efficacy of Di'ao Xinxuekang Capsules combined with atorvastatin in treatment of stable angina pectoris.Methods Patients(136 cases)with stable angina pectoris in the First People's Hospital of Wuhu from March 2021 to March 2023 were divided into control(68 cases)and treatment(68 cases)group by random number table method.Patients in the control group were po administered with Atorvastatin Calcium Tablets,20 mg/time,once daily.Patients in the treatment group were po administered with Di'ao Xinxuekang Capsules on the basis of the control group,2 grains/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical evaluations were evaluated,the levels of TCM symptom scores,total cholesterol,LDL-C,non-HDL-C,CRP,TNF-α and IL-1β in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the control group was 80.88%,which was significantly lower than that of the treatment group(92.65%,P＜0.05).After treatment,the scores of shortness of breath,chest pain,palpitation and chest tightness in the two groups were significantly decreased(P＜0.05),and the scores of TCM symptoms in the treatment group were lower than those in the control group(P＜0.05).After treatment,the levels of total cholesterol,LDL-C,non-HDL-C,CRP,TNF-α and IL-1β in two groups were significantly lower than those before treatment(P＜0.05),and the decrease in the treatment group was higher than that in the control group(P＜0.05).Conclusion The combination of Di'ao Xinxuekang Capsules combined with atorvastatin is safe and effective in treatment of stable angina pectoris,which can significantly improve the patient's blood lipid levels and inflammatory status,which is an effective clinical treatment for stable angina pectoris.
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