Clinical study on Linaoxin Tablets combined with ticagrelor in treatment of unstable angina pectoris
Objective To explore the clinical efficacy of Linaoxin Tablets combined with ticagrelor in treatment of unstable angina pectoris.Methods A total of 96 patients with unstable angina pectoris treated in Daxing District People's Hospital of Beijing from March 2021 to February 2023 were selected and divided into control group(48 cases)and treatment group(48 cases)by random number table method.Patients in the control group were po administered with Ticagrelor Tablets,the initial loading dose was 180 mg,and then the dose was changed to 90 mg/time,twice daily.Patients in the treatment group were po administered with Linaoxin Tablets on the basis of the control group,3 tablets/time,three times daily.Patients in two groups were treated for 6 months.After treatment,the clinical evaluations were evaluated,the levels of PRI,MAADP,CRP,MCP-1,and MMP-9 in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 93.75%,which was significantly higher than that of the control group(79.17%,P＜0.05).After treatment,the levels of PRI,MAADP,CRP,MCP-1,and MMP-9 in two groups were lower than those before treatment(P＜0.05),and these indexes levels in the treatment group were significantly lower than the control group(P＜0.05).Conclusion Linaoxin Tablets combined with ticagrelor is safe and effective in treatment of unstable angina pectoris,can effectively reduce the risk of thrombosis without increasing the risk of bleeding and improve the inflammatory response in the body.
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