Clinical study on perindopril tert-butylamine combined with digoxin in treatment of elderly congestive heart failure
Objective To explore the clinical efficacy of perindopril tert-butylamine combined with digoxin in treatment of elderly congestive heart failure.Methods Patients(115 cases)with elderly congestive heart failure in Cangzhou Central Hospital from May 2022 to May 2023 were randomly divided into control(57 cases)and treatment(58 cases)group.Patients in the control group were po administered with Digoxin Tablets,0.25 mg/time,once daily.Patients in the treatment group were po administered with Perindopril tert-Butylamine Tablets on the basis of the control group,4 mg/time,once daily.Patients in two groups were treated for 8 weeks.After treatment,the clinical evaluations were evaluated,the quality of life and exercise endurance,the levels of ventricular remodeling indicators LVPWT,LVPWd,LVPWs and LVSId,the levels of serum Clusterin,Cys-C,sICAM-1 and Hcy in two groups before and after treatment were compared.Results After treatment,the total clinical effective rate of the treatment group and the control group was 93.10%and 75.44%respectively(P＜0.05).After treatment,the MLHFQ score was significantly decreased,and the 6 min walking distance was significantly increased in two groups(P＜0.05),and the MLHFQ score and 6 min walking distance were significantly improved in the treatment group(P＜0.05).After treatment,the levels of LVPWT,LVPWd,LVPWs,LVSId,Clusterin,Cys-C,sICAM-1 and Hcy in the two groups were significantly decreased(P＜0.05),and the levels of these indexes in the treatment group were significantly lower than those in the control group(P＜0.05).Conclusion The combination of perindopril tert butylamine and digoxin tablets has a significant therapeutic effect on elderly patients with congestive heart failure.It can not only significantly improve exercise endurance and quality of life,but also promote the recovery of serological indicators and effectively inhibit ventricular remodeling,which has clinical promotion value.
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