Clinical study on Huoxin Pills combined with ivabradine in treatment of stable angina pectoris
Objective To investigate the clinical effect of Huoxin Pills combined with Ivabradine Hydrochloride Tablets in treatment of stable angina pectoris.Methods Patients(102 cases)with stable angina pectoris in Xingbin District People's Hospital of Laibin City from April 2021 to May 2023 were divided into control and treatment groups according to the random number table method,with 51 cases in each group.Patients in the control group were po administered with Ivabradine Hydrochloride Tablets,1 tablet/time,twice daily.Patients in the treatment group were po administered with Huoxin Pills on the basis of the control group,2 pills/time,twice daily.Therapeutic effect was evaluated after 8 weeks of treatment.The total effective rates,symptoms of angina pectoris,the degree of coronary stenosis,and the serum markers in two groups were compared.Results After treatment,the total effective rate of the treatment group was 94.12%,while the total effective rate of the control group was 80.39%,with a significant difference between the groups(P＜0.05).After treatment,the frequency of angina attacks,the duration of pain,VAS score,and Gensini score in two groups were significantly decreased(P＜0.05),and the frequency of angina attacks,the duration of pain,VAS score,and Gensini score in the treatment group were lower than those in the control group(P＜0.05).After treatment,the serum levels of LOX-1 and HMGB1 in two groups were lower than before treatment,but serum levels of SRAGE in two groups were higher than before treatment(P＜0.05).The serum levels of LOX-1 and HMGB1 in the treatment group were lower than those in the control group,but the serum levels of SRAGE in the treatment group were higher than those in the control group(P＜0.05).Conclusion Huoxin Pills combined with Ivabradine Hydrochloride Tablets can improve the clinical efficacy of stable angina,alleviate symptoms of angina,reduce the degree of coronary artery stenosis,and inflammatory response.
Huoxin PillsIvabradine Hydrochloride Tabletsfrequencystable angina pectorisduration of painVAS scoreGensini scoreLOX-1HMGB1SRAGE
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