Clinical study on Mailuo Shutong Pills combined with low molecular weight heparin in treatment of lower extremity arteriosclerosis obliterans
Objective To investigate the clinical effect of Mailuo Shutong Pills combined with Low Molecular Weight Heparin Calcium Injection in treatment of lower extremity arteriosclerosis obliterans.Methods Patients(130 cases)with lower extremity arteriosclerosis obliterans in Langfang People's Hospital from January 2020 to January 2023 were divided into control and treatment groups according to the random number table method,and each group had 65 cases.Patients in the control group were sc injected with Low Molecular Weight Heparin Calcium Injection,1 dose/time,twice daily.Patients in the treatment group were po administered with Mailuo Shutong Pills after a meal on the basis of the control group,12 g/time,three times daily.Patients in two groups were treated for 7 d.The clinical efficacies,walking distance,ultrasound parameters,and serum indicators in two groups were compared.Results After treatment,the total effective rate of the treatment group was significantly higher than that of the control group,with a significant difference(P＜0.05).After treatment,the longest walking distance and painless walking distance of two groups were significantly increased(P＜0.05),and the longest walking distance and painless walking distance of the treatment group were significantly longer than those of the control group(P＜0.05).After treatment,ABI,femoral artery blood flow velocity,and dorsalis pedis artery blood flow velocity of two groups were significantly increased(P＜0.05),and ABI,femoral artery blood flow velocity,and dorsalis pedis artery blood flow velocity of the treatment group were significantly higher than those of the control group(P＜0.05).After treatment,the serum levels of CD163,TGF-β1,and IL-17 in both groups were significantly reduced(P＜0.05),and the serum levels of CD163,TGF-β1,and IL-17 in the treatment group were significantly lower than those in the control group(P＜0.05).Conclusion Mailuo Shutong Pills combined with Low Molecular Weight Heparin Calcium Injection can improve the efficacy of lower extremity arteriosclerosis obliterans,increase the walking distance,improve lower limb blood flow velocity,and reduce inflammatory reactions.
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