Clinical study of Shiliu Buxue Syrup combined with iron sucrose in treatment of postoperative iron deficiency anemia
Objective To explore the clinical efficacy of Shiliu Buxue Syrup combined with iron sucrose in treatment of postoperative iron deficiency anemia.Methods Ninety-six patients with postoperative iron deficiency anemia admitted to Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from March 2021 to March 2023 were selected and divided into control group and treatment group according to random number table method,with 48 cases in each group.Patients in the control group were iv administered with Iron Sucrose Injection,0.9%sodium chloride injection 100 mL added Iron Sucrose Injection 100 mg,3 times weekly.Patients in the treatment group were po administered with Shiliu Buxue Syrup on the basis of the control group,20 mL/time,3 times daily.Both groups were treated for 30 d.The clinical efficacy and symptom remission time of the two groups were observed,and the changes of blood routine indexes and serum inflammatory factors before and after treatment were compared.Results After treatment,the total effective rate of treatment group was 97.92%,which was significantly higher than that of control group(81.25%,P＜0.05).After treatment,the improvement time of fatigue,palpitation,dizziness,and pale skin mucosa in treatment group was significantly shorter than that in control group(P＜0.05).After treatment,the levels of hemoglobin(HGB),serum ferritin(SF),transferrin saturation(TS),and hematocrit(HCT)in 2 groups were significantly increased compared with before treatment(P＜0.05).After treatment,the HGB,SF,TS,and HCT levels in the treatment group were higher than those in control group(P＜0.05).After treatment,the levels of interleukin-6(IL-6),membrane-bound serine proteinase-2(MTPS-2),serum ferritin(Hepcidin),and tumor necrosis factor-α(TNF-α)in 2 groups were significantly decreased compared with those before treatment(P＜0.05).After treatment,the levels of IL-6,MTPS-2,Hepcidin,and TNF-α in the treatment group were significantly lower than those in control group(P＜0.05).Conclusion Shiliu Buxue Syrup combined with iron sucrose has good clinical effect in treatment of postoperative iron deficiency anemia,and can obviously improve the anemia state of patients,increase the iron level in the body,which can weaken the postoperative inflammatory response.
Shiliu Buxue SyrupIron Sucrose Injectionpostoperative iron deficiency anemiasymptom improvement timeHGBSFTSHCTIL-6MTPS-2Hepcidin
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