Clinical study on Xiao'er Dingchuan Oral Liquid combined with salbutamol sulfate in treatment of mild to moderate bronchial asthma in children
Objective To explore the clinical effect of Xiao'er Dingchuan Oral Liquid combined with salbutamol sulfate in treatment of mild to moderate bronchial asthma in children.Methods Children(90 cases)with mild to moderate bronchial asthma in Henan Children's Hospital from July 2022 to July 2023 were randomly divided into control(45 cases)and treatment(45 cases)group.Children in the control group were administered with Salbutamol Sulfate Inhalation Aerosol,100 µg/time,once every 6 h.Children in the treatment group were po administered with Xiao'er Dingchuan Oral Liquid on the basis of the control group,10 mL/time,three time daily.Children in two groups were treated for 7 d.After treatment,the clinical evaluations were evaluated,the symptom relief time,the levels of serum SOD,ET,NO,IL-6,PCT,LTC4 and INF-γ,and adverse reactions in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 97.78%,which was significantly higher than that of the control group(82.22%,P＜0.05).After treatment,the time of symptom improvement in the treatment group was significantly earlier than that in the control group(P＜0.05).After treatment,the levels of SOD and INF-γ were significantly increased,while the levels of ET,NO,IL-6,PCT and LTC4 were significantly decreased in two groups(P＜0.05),and these indexes in the treatment group were significantly better than those in the control group(P＜0.05).The incidence of adverse reactions in the treatment group(6.67%)was significantly lower than that in the control group(19.78%)(P＜0.05).Conclusion Xiao'er Dingchuan Oral Liquid combined with salbutamol sulfate in treatment of mild to moderate bronchial asthma in children can effectively improve the oxidative stress response and reduce the bronchial inflammatory response.
Xiao'er Dingchuan Oral LiquidSalbutamol Sulfate Inhalation Aerosolmild to moderate bronchial asthma in childrenSODETPCT
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