Clinical study of Xiaoer Resuqing Oral Liquid combined with erythromycin cyclocarbonate in treatment of acute upper respiratory tract infection in children
Objective To analyze the clinical efficacy of Xiaoer Resuqing Oral Liquid combined with erythromycin cyclocarbonate in treatment of acute upper respiratory tract infection in children.Methods A total of 116 children with acute upper respiratory tract infection treated in Tongzhou District Maternal and Child Health Hospital of Beijing from January to December 2022 were selected and divided into control group and treatment group according to random number table method,with 58 cases in each group.Children in the control group were po administered with Erythromycin Cyclocarbonate for Suspension,15 mg/kg,once every 12 h,dissolved it in cold water,shaked well,and then took it orally.Children in the treatment group were po administered with Xiaoer Resuqing Oral Liquid,1≤age≤3 years old,3 years old＜age≤6 years old,6 years old＜age≤12 years old were given 10,15,20 mL/time,3 times daily,respectively.Both groups were treated for 5 d.The clinical effect,the time of complete fever remission and the time of other symptoms disappearance were observed.The scores of Sleep habits Questionnaire(CSHQ),Subjective Quality of Life Questionnaire(ISLQ),whole blood white blood cell count(WBC),erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)were compared between two groups before and after treatment.Results After treatment,the total effective rate of the treatment group was 94.83%,which was significantly higher than that of the control group(84.48%)(P＜0.05).The time of complete remission of fever and the disappearance time of nasal obstruction,runny nose,swollen tonsils,aching body,sore throat and cough in treatment group were significantly shorter than those in control group(P＜0.05).After treatment,CSHQ score was significantly decreased,but ISLQ score was significantly increased in both groups(P＜0.05).After treatment,CSHQ and ISLQ scores in treatment group were significantly improved(P＜0.05).After treatment,whole blood WBC,ESR and CRP levels were significantly decreased in both groups(P＜0.05).The decrease was more significant in treatment group(P＜0.05).Conclusion Xiaoer Resuqing Oral Liquid combined with erythromycin cyclocarbonate has definite curative effect in treatment of acute upper respiratory tract infection in children,and can accelerate the improvement of children's symptoms and signs,reduce the sleep degree and life quality affected,which is worthy of clinical application.
Xiaoer Resuqing Oral LiquidErythromycin Cyclocarbonate for Suspensionacute upper respiratory tract infection in childrentime of complete regression of feverISLQ scoreESRCRP
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