Clinical study on Guifu Dihuang Pills combined with irbesartan in the treatment of diabetes nephropathy
Objective To explore the clinical efficacy of Guifu Dihuang Pills combined with irbesartan in the treatment of diabetes nephropathy.Methods Patients(104 cases)with diabetes nephropathy in the 73rd Group Army Hospital of the PLA from January 2021 to April 2023 were divided into control(52 cases)and treatment(52 cases)group by random number table method.Patients in the control group were po administered with Irbesartan Tablets,150 mg/d.Patients in the treatment group were po administered with Guifu Dihuang Pills on the basis of the control group,8 pills/time,three times daily.Patients in two groups were treated for 3 months.After treatment,the clinical evaluations were evaluated,the levels of creatinine,UACR,urea nitrogen,hs-CRP,NLR and IL-1β,and TCM symptom scores in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was 94.23%,which was significantly higher than that of the control group(80.77%,P＜0.05).After treatment,the levels of creatinine,UACR,urea nitrogen,hs-CRP,NLR and IL-1β in two groups were significantly lower than those before treatment(P＜0.05),and the renal function and inflammatory indexes in the treatment group were significantly lower than those in the control group(P＜0.05).After treatment,the scores of limb edema,cold limbs and waist and knee tenderness in both groups were lower than before treatment(P＜0.05),and the scores of TCM symptoms in the treatment group were lower than those in the control group(P＜0.05).Conclusion Guifu Dihuang Pills combined with Irbesartan has good clinical efficacy in the treatment of diabetes nephropathy,can significantly improve the renal function and inflammatory reaction of patients,and has high safety.
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