Clinical study on Compound Lurong Jiangu Capsules combined with zoledronic acid in treatment of osteoporosis
Objective To investigate the clinical effect of Compound Lurong Jiangu Capsules combined with Zoledronic Acid Injection in treatment of osteoporosis.Methods Patients(132 cases)with osteoporosis in Tangshan People's Hospital from August 2020 to February 2023 were divided into control and treatment groups according to the computer random arrangement method,and each group had 66 cases.Patients in the control group were iv administered with Zoledronic Acid Injection,1 dose/time,once every 4 weeks.Patients in the treatment group were po administered with Compound Lurong Jiangu Capsules on the basis of the control group,5 grains/time,three times daily.Patients in two groups were treated for 6 months.The clinical efficacies,pain level,bone density,serum bone metabolism indicators,and serum inflammatory response indicators in two groups were compared.Results After treatment,the total effective rate of the treatment group(92.42%)was higher than that of the control group(80.30%),and the difference between groups was significant(P＜0.05).After treatment,NRS score of two groups was lower than before treatment(P＜0.05),and NRS score of the treatment group was lower than that of the control group(P＜0.05).After treatment,the bone density of trochanter,femoral neck,and lumbar spine in both groups was higher than that before treatment(P＜0.05),and the bone density of trochanter,femoral neck,and lumbar spine in treatment group was higher than that in control group(P＜0.05).After treatment,the levels of BGP,MMP-9,and IL-17 were lower than before treatment,but the levels of BALP and OPG were higher than before treatment(P＜0.05).After treatment,the levels of BGP,MMP-9,and IL-17 in the treatment group was lower than that in the control group,but the levels of BALP and OPG were higher than those in the control group(P＜0.05).Conclusion Compound Lurong Jiangu Capsules combined with Zoledronic Acid Injection can significantly improve the curative effect of osteoporosis,further improve bone density,regulate bone metabolism and reduce inflammation.
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