Clinical study of Gutongling Tincture combined with sodium hyaluronate in treatment of ankle arthritis
Objective To explore the clinical efficacy of Gutongling Tincture combined with sodium hyaluronate in treatment of ankle arthritis.Methods A total of 82 patients with ankle arthritis admitted to Fengfeng General Hospital of North China Medical and Health Group from June 2020 to May 2023 were selected and divided into control group and treatment group according to random number table method,with 41 cases in each group.Patients in control group were given Sodium Hyaluronate Injection,2 mL/time,once weekly.Patients in treatment group were given Gutongling Tincture,10 mL was soaked on the tape and applied to the affected area,30 min/time,once daily.Both groups were treated for 12 weeks.The clinical efficacy of two groups was observed,and the ankle joint swelling score,pain visual analogue scale(VAS)score,morning stiffness time,Kofoed ankle joint function score,AOFAS ankle and hind foot function score,36 health survey summary(SF-36)score,and serum transforming growth factor β1(TGF-β1)before and after treatment were compared.Results After treatment,the total effective rate of treatment group was 95.12%,which was significantly higher than that of the control group(80.49%,P＜0.05).After treatment,swelling score and pain VAS score were significantly decreased,and morning stiffness time was significantly shortened in both groups(P＜0.05).After treatment,swelling score,pain VAS score and morning stiffness time in treatment group were better than those in control group(P＜0.05).After treatment,the scores of pain,function,range of motion and total scores of Kofoed ankle joint function were significantly increased in both groups(P＜0.05).The increase was more significant in treatment group(P＜0.05).After treatment,AOFAS ankle and hind foot function scores and SF-36 scores were significantly increased,but serum TGF-β1 levels were significantly decreased in both groups(P＜0.05).After treatment,AOFAS ankle and hind foot function scores,SF-36 scores and serum TGF-β1 in treatment group were better than those in control group(P＜0.05).Conclusion Gutongling Tincture combined with sodium hyaluronate has better efficacy and safety in treatment of ankle arthritis,and can effectively reduce clinical symptoms,improve ankle joint function and improve life quality,and down-regulate the expression of TGF-β1 in serum to promote remission of disease.
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